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5MTHFR and Histamine Intolerance

5MTHFR and Histamine Intolerance


5MTHFR and Histamine Intolerance

The causative factors for histamine intolerance are many:

  • Genetic susceptibility: MTHFR, DAO, MAO, HNMT, PEMT, etc
  • Pathogens
  • Nutrient deficiencies: B12, folate, B6, B2, B1, Zn, Cu, C, methionine
  • Nutrient excesses: histidine, protein excess in general
  • Medications: antibiotics, antacids
  • Stress, anxiety, lack of sleep
  • Hormonal insufficiciency
  • Adrenal fatigue
  • Hormonal excess: estrogen dominance, PCOS
  • Lifestyle: excessive exercise, alcohol, decreased sleep
  • Diet
  • Environment: exposures
  • Gastrointestinal issues: leaky gut, IBD, IBS

Here is a great article relating histamine intolerance (hives)


Dr. Samantha Du Moulin has completed additional training in genetic mutations, including  5MTHFR.


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